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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SNAP25
All Species:
26.67
Human Site:
T173
Identified Species:
45.13
UniProt:
P60880
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60880
NP_003072.2
206
23315
T173
D
M
G
N
E
I
D
T
Q
N
R
Q
I
D
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001105155
211
23235
A179
N
I
G
N
E
I
D
A
Q
N
P
Q
I
K
R
Dog
Lupus familis
XP_859386
207
23459
T174
D
M
G
N
E
I
D
T
Q
N
R
Q
I
D
R
Cat
Felis silvestris
Mouse
Mus musculus
O09044
210
23242
A178
D
M
G
N
E
I
D
A
Q
N
Q
Q
I
Q
K
Rat
Rattus norvegicus
P60881
206
23297
T173
D
M
G
N
E
I
D
T
Q
N
R
Q
I
D
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507841
243
26184
I170
D
V
S
N
E
I
D
I
H
N
T
Q
V
D
K
Chicken
Gallus gallus
XP_421159
209
23585
A177
D
M
G
N
E
I
D
A
Q
N
K
Q
I
D
R
Frog
Xenopus laevis
NP_001080510
206
23168
T173
D
M
G
N
E
I
D
T
Q
N
R
Q
I
D
R
Zebra Danio
Brachydanio rerio
Q5TZ66
204
22839
T171
D
M
G
N
E
I
D
T
Q
N
R
Q
I
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P36975
212
23667
S177
N
M
A
L
D
M
G
S
E
L
E
N
Q
N
R
Honey Bee
Apis mellifera
XP_394588
213
23546
S178
N
M
A
I
D
M
G
S
E
L
E
N
Q
N
R
Nematode Worm
Caenorhab. elegans
P83351
277
31097
S212
D
L
G
K
E
V
D
S
Q
N
E
M
L
D
R
Sea Urchin
Strong. purpuratus
NP_999754
212
23995
A179
D
M
Q
S
E
I
G
A
Q
N
S
Q
V
G
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LMG8
263
29057
K231
D
M
G
S
E
I
D
K
Q
N
K
A
L
D
H
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
60.6
94.1
N.A.
61.4
100
N.A.
57.6
59.3
95.1
93.1
N.A.
60.3
60.5
22.3
60.3
Protein Similarity:
100
N.A.
76.3
97
N.A.
77.6
100
N.A.
67.9
76.5
97
96.1
N.A.
75
74.1
38.6
74.5
P-Site Identity:
100
N.A.
66.6
100
N.A.
73.3
100
N.A.
53.3
86.6
100
100
N.A.
13.3
13.3
53.3
53.3
P-Site Similarity:
100
N.A.
80
100
N.A.
86.6
100
N.A.
73.3
93.3
100
100
N.A.
53.3
53.3
80
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
80
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
15
0
0
0
0
29
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
79
0
0
0
15
0
79
0
0
0
0
0
0
65
0
% D
% Glu:
0
0
0
0
86
0
0
0
15
0
22
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
72
0
0
0
22
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% H
% Ile:
0
8
0
8
0
79
0
8
0
0
0
0
58
0
0
% I
% Lys:
0
0
0
8
0
0
0
8
0
0
15
0
0
8
15
% K
% Leu:
0
8
0
8
0
0
0
0
0
15
0
0
15
0
0
% L
% Met:
0
79
0
0
0
15
0
0
0
0
0
8
0
0
0
% M
% Asn:
22
0
0
65
0
0
0
0
0
86
0
15
0
15
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
79
0
8
72
15
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
36
0
0
0
79
% R
% Ser:
0
0
8
15
0
0
0
22
0
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
36
0
0
8
0
0
0
0
% T
% Val:
0
8
0
0
0
8
0
0
0
0
0
0
15
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _